Käänteisagonismi
Käänteisagonismi, often translated as anti-agonism or inverse agonism, is a concept in pharmacology describing a type of receptor modulation. While an agonist binds to a receptor and elicits a biological response, and an antagonist binds to a receptor but blocks the action of agonists, an inverse agonist binds to the same receptor as an agonist but produces the opposite effect. This implies that many receptors possess a basal level of activity even in the absence of an agonist.
The existence of basal receptor activity is a prerequisite for inverse agonism. If a receptor has no
Understanding inverse agonism has significant implications for drug development. It suggests that therapies could be designed