Kinesin4

Kinesin-4 is a subfamily of kinesin motor proteins. Kinesins are a large family of motor proteins found in eukaryotes that are responsible for transporting a wide variety of cellular components along microtubule tracks. Kinesin-4 proteins are characterized by their unique motor domain structure and their specific roles in cellular processes.

These kinesins are known to play crucial roles in cell division, particularly in the formation and maintenance of the spindle apparatus. They contribute to the proper positioning of chromosomes and the elongation of the spindle during anaphase. In addition to their mitotic functions, some kinesin-4 members are involved in cytoplasmic organization and the transport of organelles and vesicles within the cell.

Research has indicated that kinesin-4 proteins can interact with various adaptor proteins and cargo molecules, allowing them to selectively bind and transport specific cellular components. Their motor activity is powered by the hydrolysis of ATP, which drives conformational changes in the motor domain, enabling them to move processively along microtubules. Dysregulation of kinesin-4 function has been linked to certain diseases, including cancer, highlighting their importance in maintaining cellular homeostasis. Further investigation into the precise mechanisms and substrates of kinesin-4 motors continues to be an active area of research in cell biology.