Kinasaalista

Kinasaalista is a publicly accessible catalog that gathers information on protein kinases across eukaryotes. The name combines kinase with lista, reflecting its function as a centralized reference for researchers studying phosphorylation signaling. The catalog aims to standardize nomenclature, classification, and cross-species comparisons of kinases, providing a unified resource for the scientific community.

Entries in Kinasaalista include gene symbols and aliases, organism, catalytic class and EC number, catalytic domain architecture and regulatory regions, substrate preferences, activation mechanisms, and subcellular localization. Each entry also lists known activators and inhibitors, experimental evidence, and references, with structural data such as PDB identifiers when available. To aid comparative analyses, kinases are grouped into families according to established classifications, including tyrosine kinases, serine/threonine kinases, and dual-specificity kinases, among others.

Data in Kinasaalista are integrated from public resources such as UniProt, Pfam, and the Protein Data Bank, as well as peer-reviewed literature. A curation team conducts quality checks, and community contributors may submit updates subject to review. Releases are versioned and accompanied by change logs; programmatic access is provided via an API and downloadable datasets to support reproducible research.

The catalog serves applications in signaling pathway mapping, comparative genomics, and drug-target discovery. Limitations include uneven coverage across species and ongoing updates as new data emerge. Users are encouraged to contribute findings, report inconsistencies, and reference primary sources to maintain accuracy.