KLB

KLB is an acronym that can refer to multiple topics across different fields. In the life sciences, the most widely recognized use is as the symbol for the KLB gene, which encodes the protein beta-klotho. Beta-klotho is a transmembrane protein that forms a co-receptor with certain fibroblast growth factor receptors to enable signaling by fibroblast growth factors, notably FGF19 and FGF21. This signaling influences bile acid synthesis in the liver and plays a role in energy and glucose metabolism. The KLB gene is expressed in tissues including the liver and adipose tissue, and its activity is a focus of research on metabolic regulation. Changes in KLB expression or function are investigated for potential associations with metabolic traits and conditions.

As an acronym, KLB is used by various organizations, institutions, and companies around the world. Because there is no single dominant entity associated with the abbreviation, the meaning of KLB is highly context dependent. In academic, corporate, or geographic contexts, surrounding details such as full names, locations, or field of work are typically required to determine which specific organization or concept is being referenced.

In addition to biology and organizational uses, KLB may appear in coding systems, project names, or product designations within specialized industries. When encountering the term KLB, readers should rely on contextual information to disambiguate its intended meaning, distinguishing between the gene symbol and other potential uses.