KIRGene
KIRGene is a term used to denote a member of the killer-cell immunoglobulin-like receptor (KIR) gene family, which encodes receptors expressed on natural killer (NK) cells and some T cells. In humans, KIR genes reside in the leukocyte receptor complex on chromosome 19 and show extensive genetic variation across individuals and populations. Standard references name individual genes such as KIR2DL1 or KIR2DS4; KIRGene, when used, refers to any such member rather than a single universal locus.
Structure and diversity: KIRGene products are membrane receptors with immunoglobulin-like domains. They are categorized as inhibitory
Function: KIRGene-encoded receptors recognize polymorphic HLA class I ligands on potential target cells, regulating NK cell
Clinical relevance: Variation in KIR gene content and alleles influences immune responses with implications for transplantation,
Research and methods: Genotyping KIR genes and their HLA ligands employs targeted sequencing, multiplex PCR, and