KIF4A

KIF4A is a protein that in humans is encoded by the KIF4A gene. The protein product of this gene belongs to the kinesin superfamily of proteins, which are involved in microtubule-based motility and intracellular transport. Kinesin motors play a crucial role in various cellular processes, including cell division, intracellular transport, and organelle movement.

KIF4A is a member of a subfamily of kinesins that is involved in the regulation of mitosis and meiosis. It is localized to the kinetochore, a complex protein structure that is essential for the proper segregation of chromosomes during cell division. KIF4A has also been implicated in the regulation of the mitotic spindle, a protein structure that is responsible for the separation of chromosomes during mitosis.

Mutations in the KIF4A gene have been associated with various disorders, including premature ovarian failure, infertility, and meiotic defects. Research has also identified KIF4A as a potential tumor suppressor gene, as its expression is often reduced or absent in certain types of cancer.

Zeins are involved in various cellular processes, including microtubule-based transport, spindle assembly, and chromosome segregation. Studies have also identified KIF4A as an important regulator of genome stability, as alterations in its expression can lead to genomic instability and chromosomal abnormalities. Further research is needed to fully understand the role of KIF4A in cellular processes and its potential implications for disease.

KIF4A is widely expressed in various tissues, including the brain, testis, and ovaries, suggesting its importance in development and reproduction. Its role in various cellular processes makes KIF4A an essential component of the cell's machinery, and its dysfunction has been linked to various diseases and disorders.