Jfxn1

JFxn1 is a gene encoding a small, conserved protein of unknown precise function found in a broad range of eukaryotic genomes. The name JFxn1 is derived from its initial discovery in comparative genome analyses and its designation in subsequent annotation efforts. Across species, JFxn1 shows notable sequence conservation, suggesting an essential cellular role.

Protein features inferred from sequence data indicate a compact structure with a central coiled-coil region and a short C-terminal tail that may mediate protein-protein interactions. No experimentally solved three-dimensional structure has been reported yet, and predicted models currently rely on homology to related coiled-coil proteins.

Expression data from transcriptome analyses indicate broad, constitutive expression with enrichment in tissues associated with trafficking and signaling in several organisms, though patterns vary by lineage.

Functional data for JFxn1 are limited. Interaction studies have proposed associations with factors involved in vesicular transport and cytoskeletal organization. Genetic disruption in model systems yields modest phenotypes under stress, with more pronounced effects observed in combinations with mutations in related pathways.

Evolutionarily, orthologs of JFxn1 are found across diverse eukaryotes, indicating deep conservation. The extent of functional conservation remains an active area of study, and lineage-specific adaptations may exist.

Clinical significance to date remains unclear, with no established disease linkage. JFxn1 is frequently cited as a candidate for further functional characterization to determine its role in cell organization and signaling networks.