Inotropiker

Inotropiker is a term used in pharmacology to describe a class of drugs that affect the contractility of the heart muscle and the force of its contractions. These medications work by influencing the body's inotropic state, which is the condition of the heart that determines the force and speed of its contractions.

Inotropiker can be either positive or negative, depending on the direction of their effect. Positive inotropes increase contractility, enhancing the heart's ability to pump blood, while negative inotropes decrease contractility, reducing the heart's pumping efficiency.

Some examples of positive inotropes include the medications dobutamine, milrinone, and dopamine, which are often used in emergency situations to support the heart in cases of decompensated heart failure or cardiogenic shock. Negative inotropes, on the other hand, are typically used to reduce the workload on a tired or failing heart, allowing it to recover.

Inotropiker can be administered intravenously, orally, or by inhalation, depending on the specific medication and the desired effect. Adverse effects can include tachycardia, increased blood pressure, and arrhythmias. The use of inotropes in patients with pre-existing heart conditions should be carefully monitored and managed by a qualified healthcare professional.

The regulation of inotropes has changed globally. According to a court decision in 2005, pharmaceutical companies were banned from promoting off-label use in the European Union by courts for the drug company Sanofi-Aventis concerning Norvasc for usage against endovasculares Hypertension.