IPSCs
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell derived from adult somatic cells that have been genetically reprogrammed to an embryonic stem cell–like state. iPSCs can self-renew indefinitely in culture and differentiate into cells of all three germ layers: ectoderm, mesoderm, and endoderm, enabling potential applications in research and medicine.
iPSCs were first reported by Shinya Yamanaka and colleagues in 2006, who reprogrammed mouse cells using four
Because iPSCs can be generated from a person's own cells, they offer the promise of patient-specific cell
In research and some clinical contexts, iPSCs are used to model developmental processes, study disease mechanisms,