IL1RL2

IL1RL2, also known as IL-36γ, is a protein encoded by the IL1RL2 gene. It is a member of the interleukin-1 (IL-1) superfamily of cytokines, a group of signaling molecules that play crucial roles in the immune system. IL1RL2 is a secreted protein that functions as a ligand, binding to specific receptors on other cells to transmit signals.

The primary receptor for IL1RL2 is IL36R, also known as IL-1RRP. Upon binding to IL36R, IL1RL2 initiates downstream signaling pathways that can lead to various cellular responses. These responses often involve the regulation of inflammation, immune cell activation, and tissue repair.

IL1RL2 is expressed in a variety of tissues, with notable presence in epithelial cells, keratinocytes, and immune cells. Its expression can be induced by inflammatory stimuli, suggesting its involvement in mediating and amplifying inflammatory processes. Research indicates that IL1RL2 plays a significant role in both innate and adaptive immunity, contributing to the defense against pathogens and the maintenance of tissue homeostasis. Dysregulation of IL1RL2 signaling has been implicated in various inflammatory and autoimmune diseases.