IL12Rbeta2
IL12Rbeta2, also known as IL12RB2 or IL12RB, is a receptor subunit that plays a crucial role in the immune system. It is a type I transmembrane protein that primarily binds to the cytokine interleukin-12 (IL-12). This receptor is a component of the high-affinity IL-12 receptor, which is a heterodimer consisting of IL12Rbeta2 and the IL12Ralpha subunit (IL12RA). The IL12Rbeta2 subunit itself is a distinct protein that associates with other receptor chains to form functional receptors.
The expression of IL12Rbeta2 is predominantly found on T helper 1 (Th1) cells, natural killer (NK) cells,
The biological consequences of IL-12Rbeta2 engagement by IL-12 are significant. It is critical for the differentiation
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