Hüübimisproove

Hüübimisproove, also known as coagulation tests, are a group of laboratory tests used to evaluate the blood's ability to clot. These tests assess the various components of the coagulation cascade, a complex series of protein interactions that ultimately leads to the formation of a stable fibrin clot. By measuring the time it takes for blood to clot or by quantifying specific clotting factors, these tests can help diagnose and monitor bleeding disorders, thrombotic conditions, and the effectiveness of anticoagulant therapy.

Commonly performed hüübimisproove include the Prothrombin Time (PT) and the Activated Partial Thromboplastin Time (aPTT). The PT measures the extrinsic pathway of coagulation, while the aPTT assesses the intrinsic pathway. Both tests are sensitive to deficiencies in multiple clotting factors. Other specialized tests may be used to measure the levels of specific clotting factors or to detect the presence of inhibitors that interfere with clotting.

These tests are crucial in pre-operative assessment to identify patients at risk of excessive bleeding, in the management of patients taking anticoagulant medications like warfarin or heparin, and in the investigation of unexplained bruising, bleeding, or thrombosis. Abnormal results can indicate underlying liver disease, vitamin K deficiency, genetic clotting factor deficiencies, or the presence of autoimmune disorders affecting coagulation. Understanding the results of hüübimisproove allows for appropriate diagnosis and targeted treatment.