HTR10

HTR10, or 5-hydroxytryptamine receptor 10, is a gene that encodes a member of the serotonin receptor family. As a putative G protein-coupled receptor, HTR10 is categorized among the class of seven-transmembrane receptors that respond to the neurotransmitter serotonin (5-HT). The receptor's endogenous ligand and precise physiological role have not been conclusively established, so HTR10 is often described as an orphan receptor.

Genetic and protein features: The HTR10 gene is predicted to encode a multi-pass membrane protein with seven transmembrane domains, consistent with other serotonin receptors. Sequence analyses place HTR10 within the broader 5-HT receptor family, though its sequence conservation relative to well-characterized receptors is limited.

Expression: Expression patterns reported in some studies include brain tissues and peripheral sites, but comprehensive, reproducible expression data are scarce.

Function and signaling: There is no consensus on G protein coupling or downstream signaling for HTR10. Functional studies are sparse and have not established a defined physiological pathway or role.

Ligand pharmacology: At present, no selective endogenous or exogenous ligands have been reliably described for HTR10, reinforcing its status as an orphan receptor.

Clinical significance: No validated disease associations have been confirmed for HTR10. It has appeared in exploratory genetic studies without consistent replication.

See also: Serotonin receptor, G protein-coupled receptor, orphan receptor.