HORMAdomainlike
HORMAdomainlike refers to protein regions or whole proteins that show structural or sequence similarity to the HORMA domain, a conserved module named for its presence in Hop1, Rev7, and MAD2. The HORMA domain is involved in protein–protein interactions and can undergo conformational changes between open and closed states, often in association with a closure motif. HORMAdomainlike annotations typically arise in bioinformatic analyses when an uncharacterized protein region yields a detectable resemblance to known HORMA domains through profile-based methods or comparative structural modeling.
Key features of HORMAdomainlike regions include a core fold resembling the HORMA domain and, in some cases,
Identification approaches combine computational and experimental strategies. Computationally, researchers use hidden Markov models and other profile-based