HEN2

HEN2, also known as heat shock protein 2 (HSP2) or Heat Shock Factor Binding Protein 1 (HSFBP1), is a protein encoded by the HSFBP1 gene in humans. It belongs to the heat shock protein family, which are molecular chaperones that play a crucial role in cellular stress response. These proteins are expressed in response to various environmental stresses, including heat shock, oxidative stress, and heavy metal exposure.

The primary function of HEN2 is to assist in protein folding and to prevent protein aggregation under stress conditions. It achieves this by binding to unfolded or misfolded proteins, helping them to refold correctly or targeting them for degradation. This chaperone activity is vital for maintaining cellular homeostasis and preventing the accumulation of damaged proteins, which can lead to cellular dysfunction and disease.

HEN2 has been implicated in a variety of cellular processes beyond stress response, including cell growth, differentiation, and apoptosis. Its presence has been observed in different cellular compartments, including the cytoplasm and nucleus, suggesting diverse roles. Research has also explored its potential involvement in the pathogenesis of certain diseases, such as cancer and neurodegenerative disorders, due to its impact on protein stability and cellular survival. Further investigation continues to elucidate the full spectrum of HEN2's functions and its implications in health and disease.