Hüübimispuudulikkused

Hüübimispuudulikkused refer to a group of inherited or acquired disorders that impair the blood's ability to clot properly. This can lead to excessive bleeding after injury, spontaneous bruising, or prolonged bleeding from minor wounds. The underlying cause is typically a deficiency or dysfunction of one or more clotting factors, which are proteins essential for the coagulation cascade.

Inherited forms of hüübimispuudulikkused include hemophilia A and B, characterized by a deficiency in factors VIII and IX respectively, and von Willebrand disease, a deficiency or defect in von Willebrand factor. These conditions are often diagnosed in childhood and require lifelong management. Acquired hüübimispuudulikkused can arise from various factors such as liver disease, vitamin K deficiency, disseminated intravascular coagulation (DIC), or as a side effect of certain medications like anticoagulants.

Symptoms vary depending on the severity of the clotting factor deficiency and can range from mild bruising to life-threatening hemorrhages. Diagnosis involves blood tests to measure clotting factor levels and assess overall coagulation function. Treatment strategies depend on the specific disorder and may include factor replacement therapy, medications to promote clotting, or management of the underlying cause in acquired cases. Genetic counseling is important for individuals with inherited bleeding disorders.