Gq11proteiner

Gq11proteiner refers to a family of G protein-coupled receptors (GPCRs) that are involved in signal transduction pathways. These receptors are characterized by their seven transmembrane domains and their ability to interact with heterotrimeric G proteins, specifically those of the Gq/11 family. Upon activation by an extracellular ligand, Gq/11 proteins undergo a conformational change and facilitate the exchange of GDP for GTP on the alpha subunit of the G protein. This activated G protein then dissociates and interacts with downstream effector proteins, such as phospholipase C. The activation of phospholipase C leads to the production of second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG), which in turn trigger various cellular responses, including calcium mobilization and protein kinase C activation. Gq/11 proteins are widely expressed in various tissues and play crucial roles in a multitude of physiological processes, such as neurotransmission, hormonal regulation, and sensory perception. Dysregulation of Gq/11 signaling has been implicated in several diseases, including cancer and cardiovascular disorders, making them important targets for therapeutic intervention.