Gewebezone

Gewebezone is a term used in biology, medicine and related fields to describe a spatially defined region within tissue that shows distinct characteristics compared with surrounding tissue. The concept emphasizes gradients, boundaries and functional differences that exist within an organ, tumor, wound bed or developing tissue.

In anatomy and histology, Gewebezonen correspond to zones or compartments with specific cellular composition, activity or extracellular matrix. Examples include layers within an organ or tissue, such as different zones of a hepatic lobule with varying metabolic activities, or layers of the skin that differ in cell types and functions. The idea of zones helps explain regional specialization within an otherwise continuous tissue.

In pathology and oncology, tissue zones often reflect physiological gradients or disease processes. Commonly described are necrotic zones, hypoxic zones, proliferative zones, and inflammatory zones, which arise from variations in blood supply, oxygen, nutrients or cellular states. The margins around tumors, sometimes termed invasive or peritumoral zones, are also clinically important for understanding spread and treatment response.

In development and botany, Gewebezonen can denote regions of active growth, differentiation or meristematic activity, where cells transition from one developmental state to another.

Study and identification of Gewebezonen rely on histological examination, imaging techniques, and molecular assays that reveal differences in cell types, vascularization, extracellular matrix and gene expression. Recognizing zones aids in diagnosis, staging, and research into tissue function, regeneration and disease progression.