GSTT1present
GSTT1present is a genetic designation indicating the GSTT1 gene is present (not deleted) in an individual's genome. GSTT1 belongs to the theta class of glutathione S-transferases and participates in the detoxification of electrophilic compounds by conjugating them with glutathione. The presence of GSTT1 allows for the production of theta-class GST enzymes, though actual enzyme activity depends on expression, copy number, and regulation. A common variant is GSTT1 null (absent) due to a gene deletion, in which case no functional GSTT1 enzyme is produced.
The GSTT1 gene is located on chromosome 22q11.23. A deletion variant can result in a GSTT1-null genotype,
In research, GSTT1present status has been examined in relation to disease risk and drug response. Since GSTT1