GSTK1

GSTK1 is a gene that in humans is encoded by the GSTK1 gene. It plays a role in the detoxification of various substances by conjugating them with glutathione, making them more soluble in water and easier to excrete from the body. The protein encoded by this gene is a member of the glutathione S-transferase family, which is involved in the post-translational modification of proteins by conjugating glutathione to a variety of molecules.

Research has shown that the GSTK1 gene is involved in the regulation of cell proliferation, partly through its ability to remove harmful substances from cells. It is also thought to play a role in the innate immune system, helping to defend against bacterial infections. The gene is widely expressed in various tissues throughout the body.

GSTM and GSTK families are significant regulatory factors in pain perception. They regulate inflammatory hypersensitivity by detoxifying arachidonic acid metabolites and similarly, modulating accumulation of these metabolites in the nociceptors. Variations in these genes may have an association with inflammatory-based pain or gustatory pain sensitivity. Additionally, molecular modifications inłąpreneur of these gene families may progress in diverse forms of fibrosis such as fibrosing disorders.

Several studies have identified associations between the GSTK1 gene and various diseases and conditions, including cancer, diabetes, and inflammatory diseases. These associations may be related to the gene's role in detoxification and its ability to regulate cell proliferation and immune responses. Further research is needed to fully understand the function of the GSTK1 gene and its implications for human health.