GSK3B

Glycogen synthase kinase 3 beta, often abbreviated as GSK3B, is a protein-coding gene. The protein encoded by this gene is a serine/threonine kinase that plays a crucial role in a wide array of cellular processes. These processes include metabolism, neuronal development, and cell proliferation. GSK3B is a member of the glycogen synthase kinase 3 family and is known to be regulated by numerous signaling pathways.

The GSK3B protein is constitutively active in many cell types. However, its activity can be modulated by various post-translational modifications, such as phosphorylation. It is a key downstream target of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, which is involved in cell growth and survival. GSK3B phosphorylates a broad range of substrates, including enzymes, transcription factors, and structural proteins, thereby influencing their activity and localization.

Dysregulation of GSK3B activity has been implicated in a variety of human diseases. These include neurodegenerative disorders like Alzheimer's disease and Parkinson's disease, as well as psychiatric disorders such as bipolar disorder and schizophrenia. Furthermore, GSK3B has been linked to the development of cancer and diabetes. Due to its central role in diverse cellular functions and its involvement in disease, GSK3B has become a significant target for therapeutic interventions. Researchers are actively investigating small molecules that can modulate GSK3B activity for the treatment of these conditions.