FtsYFfh
FtsYFfh refers to a pair of proteins, **FtsY** and **Ffh**, which are essential components of the bacterial protein translocation machinery. These proteins play a critical role in targeting and inserting nascent polypeptide chains into the bacterial cell membrane, particularly those destined for secretion or incorporation into the membrane. FtsY is a soluble GTPase located in the cytoplasm, while Ffh is a ribosome-associated protein that binds to the ribosome during translation elongation.
Ffh, also known as the signal recognition particle (SRP) receptor component, interacts with the SRP RNA and
The interaction between FtsY and Ffh is regulated by GTP binding and hydrolysis. FtsY binds GTP in
Mutations or disruptions in FtsY or Ffh can impair protein translocation, leading to misfolded or improperly