Fibrinogenersatztherapie

Fibrinogenersatztherapie, also known as fibrinogen replacement therapy, is a medical treatment used to replenish low levels of fibrinogen in the blood. Fibrinogen is a crucial protein produced by the liver that plays a vital role in blood clotting. When its levels are insufficient, either due to genetic disorders like congenital afibrinogenemia or acquired conditions such as disseminated intravascular coagulation (DIC) or severe liver disease, the body's ability to form stable blood clots is impaired. This can lead to excessive bleeding and an increased risk of hemorrhage.

The therapy involves administering exogenous fibrinogen, typically derived from human plasma or produced recombinantly, to raise the patient's fibrinogen concentration to a safe level. This helps restore normal hemostasis and prevent or control bleeding episodes. Fibrinogen concentrate is usually administered intravenously. The decision to initiate fibrinogen replacement therapy and the appropriate dosage are based on the patient's clinical condition, the severity of bleeding, and their measured fibrinogen levels. It is an essential component in the management of various bleeding disorders and is often used in emergency situations and surgical procedures where bleeding risk is high. Regular monitoring of fibrinogen levels and clotting function is important during and after treatment.