FibrinSealants
Fibrin sealants are medical adhesives used to promote hemostasis and tissue sealing during surgery. They consist of a fibrinogen component and a thrombin component, which when combined in the operative field form a fibrin clot that adheres to tissue and seals surfaces. Many products also include calcium, factor XIII, and antifibrinolytic agents to improve clot stability and longevity.
These products may be derived from autologous plasma (the patient’s own blood), allogeneic human plasma, or animal
Fibrin sealants are typically supplied as two ready-to-use components that are applied sequentially with an applicator
Used across specialties including cardiovascular, hepatic, neurosurgical, orthopedic, ENT, ophthalmology, and dentistry. They can reduce intraoperative
Safety considerations include risks of infectious transmission (mitigated by donor screening and viral inactivation), hypersensitivity to