FboxWD40repeat
FboxWD40repeat is a class of eukaryotic proteins characterized by the combination of an F-box motif and WD40 repeats. The F-box domain mediates binding to SKP1, linking the protein to the Skp1-CUL1-F-box (SCF) ubiquitin ligase complex. The WD40 repeats form a beta-propeller scaffold that enables specific protein–protein interactions, providing the recognition surface for substrates. Together, these features allow FboxWD40repeat proteins to act as substrate receptors within SCF E3 ubiquitin ligases, directing ubiquitination and often proteasomal degradation of target proteins.
In most organisms, these proteins belong to the FBXW family, which comprises F-box and WD40-repeat-containing proteins,
Functional diversity arises from variation in WD40-repeat number and substrate-binding surfaces, enabling a wide range of
Research staying power: FboxWD40repeat proteins are investigated for their roles in development, cancer, immunity, and proteostasis,