FBXW7

FBXW7, also known as F-box protein 7, is a protein that plays a crucial role in cellular processes as a component of the SCF E3 ubiquitin ligase complex. This complex is responsible for targeting specific proteins for degradation by the proteasome, a cellular machinery that breaks down unwanted or damaged proteins. FBXW7 acts as a substrate recognition component, identifying which proteins should be marked for destruction.

The FBXW7 protein itself is encoded by the FBXW7 gene. It is involved in regulating the levels of various important cellular proteins, including those involved in cell cycle progression, DNA repair, and signal transduction. This regulation is critical for maintaining cellular homeostasis and preventing uncontrolled cell growth.

Dysregulation of FBXW7 activity has been implicated in the development and progression of several diseases, most notably cancer. Mutations or altered expression of FBXW7 can lead to the accumulation of oncogenic proteins, promoting tumor formation and growth. Consequently, FBXW7 is considered a tumor suppressor gene, and its loss of function is a common event in various cancers. Research continues to explore the precise mechanisms by which FBXW7 functions and its potential as a therapeutic target.