Farnesylpyrophosphat
Farnesylpyrophosphat, more commonly known as farnesyl pyrophosphate (FPP), is an allylic isoprenoid compound bearing a pyrophosphate group. It is an essential intermediate in the mevalonate pathway, participating in the biosynthesis of cholesterol, other isoprenoids, and prenylated proteins.
FPP is formed in cells by the condensation of isopentenyl pyrophosphate (IPP) with dimethylallyl pyrophosphate (DMAPP)
FPP serves as a key branch point metabolite. It is a substrate for squalene synthase, which converts
Clinical and pharmacological relevance
Because FPP is central to the mevalonate pathway, its production is influenced by statins and other pathway
See also: mevalonate pathway, farnesyltransferase, protein prenylation, cholesterol biosynthesis, isoprenoids.