FamFG

FamFG is an acronym that appears in multiple domains, and there is no single, widely accepted definition. In biology and bioinformatics, “Fam” is a common prefix used in gene nomenclature to denote a family with sequence similarity. The combination “FamFG” may be used informally to label a particular family or cluster of genes or proteins identified in a study, database, or analysis pipeline. Because different sources may define it differently, the scope and membership of FamFG are contingent on the source and should be checked in the relevant publication or database entry.

Biological significance: When used in genomics or proteomics, FamFG typically refers to a set of homologous genes sharing conserved motifs or domains. Researchers use sequence alignment and phylogenetic analyses to determine which genes belong to the family, to illuminate evolutionary relationships, and to infer potential functional similarities. Functional annotation is often provisional and subject to experimental validation.

Other contexts: In fields outside biology, FamFG might appear as an acronym for a different concept, such as a “family of finite groups” in mathematics or a label for a data-organization scheme in software. In all cases, the exact meaning is defined where the term first appears, and subsequent references should specify the intended interpretation.

See also: FAM gene family, gene family, protein family. If you have a specific source or field in mind for FamFG, providing that context will help tailor a precise definition.