FGFR23

FGFR23, also known as fibroblast growth factor receptor 23, is a protein that in humans is encoded by the FGFR23 gene. This gene is located on chromosome 10q24.3. FGFR23 is a member of the fibroblast growth factor receptor (FGFR) family, which plays a crucial role in various biological processes, including cell proliferation, differentiation, and survival.

FGFR23 is a tyrosine kinase receptor that binds to fibroblast growth factors (FGFs), specifically FGF19 and FGF21. These FGFs are involved in metabolic regulation, particularly in lipid and glucose metabolism. The FGFR23 gene is highly expressed in tissues such as the liver, adipose tissue, and skeletal muscle, where it contributes to the regulation of energy homeostasis.

Mutations in the FGFR23 gene have been associated with several clinical conditions, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease. These conditions are collectively known as the metabolic syndrome. The exact mechanisms by which FGFR23 mutations lead to these metabolic disorders are not fully understood, but they are thought to involve altered signaling pathways that affect energy metabolism.

Research into FGFR23 and its role in metabolic regulation is ongoing, with the aim of developing therapeutic strategies to treat metabolic disorders. Understanding the molecular mechanisms underlying FGFR23 function and its interactions with other signaling pathways is essential for this research.