FCGR2C

FCGR2C, also known as Fc gamma receptor IIc, is a protein-coding gene. This gene encodes a low-affinity receptor for the Fc portion of immunoglobulin G (IgG). FCGR2C is a member of the immunoglobulin superfamily and is expressed on various immune cells, including B cells and some myeloid cells. Its primary function is to mediate antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. When IgG antibodies bind to a target, such as a pathogen or infected cell, FCGR2C on the surface of an effector cell can bind to the Fc portion of these antibodies. This binding triggers downstream signaling pathways, leading to the activation of the effector cell. In the case of ADCC, this activation results in the release of cytotoxic molecules that kill the target cell. For phagocytosis, the binding promotes the engulfment and destruction of the antibody-coated target. Variations in the FCGR2C gene can influence an individual's susceptibility to certain autoimmune diseases and infections, as well as their response to antibody-based therapies. The protein's interaction with IgG is crucial for adaptive immunity and the clearance of antibody-opsonized targets.