EthR
EthR is a transcriptional regulator in Mycobacterium tuberculosis. It is a member of the TetR family of repressors and acts as a cytosolic DNA-binding protein that controls the expression of ethA, a monooxygenase required to activate the antitubercular prodrug ethionamide.
Mechanism and regulation: EthR binds to the promoter region of ethA, repressing its transcription. Small-molecule ligands
Biological significance: By modulating EthA expression, EthR influences the efficacy of ethionamide, since EthA is needed
Therapeutic relevance: EthR inhibitors have been investigated as potential adjuvants to enhance ethionamide efficacy and address
Structure and genetics: EthR is encoded in the M. tuberculosis genome and adopts a typical TetR-family fold,