EphrinEph
Ephrin-Eph signaling refers to the interaction between the Eph family of receptor tyrosine kinases and their membrane-bound ephrin ligands. The Eph family is the largest family of receptor tyrosine kinases dedicated to this mode of signaling and is divided into two subclasses: EphA receptors that preferentially bind glycosylphosphatidylinositol-anchored ephrin-A ligands, and EphB receptors that bind transmembrane ephrin-B ligands. Ephrin-A ligands are GPI-anchored and lack cytoplasmic domains, while ephrin-B ligands are transmembrane and possess intracellular tails capable of signaling.
Signaling is bidirectional: forward signaling occurs in the Eph-expressing cell upon ligand binding and receptor clustering,
Biological roles are diverse: they are crucial in embryonic development and tissue patterning, including axon guidance,