Endosomeja
Endosomeja are membrane-bound organelles within eukaryotic cells that function as central hubs in endocytosis and intracellular trafficking. They originate when vesicles carrying material from the plasma membrane fuse to form early endosomes. Early endosomes act as sorting stations, and their identity is marked by Rab5 and associated proteins such as EEA1. As they mature, endosomeja undergo acidification and biochemical changes that drive cargo sorting and trafficking decisions.
Maturation progresses from early to late endosomes, which are typically marked by Rab7 and a more acidic
Endosomeja contribute to multiple cellular processes beyond cargo degradation, including receptor downregulation, nutrient uptake, antigen presentation,
Dysfunction of endosomeja or related trafficking pathways has been linked to human disease. Altered endosomal pH,