EGFRrelated
EGFRrelated refers to phenomena and research connected with the epidermal growth factor receptor (EGFR), also known as ERBB1. EGFR-related alterations include mutations, amplifications, overexpression, or variant receptors that influence signaling and cellular behavior. EGFR is a transmembrane receptor tyrosine kinase in the ERBB family. It binds ligands such as epidermal growth factor, triggering receptor dimerization, autophosphorylation, and activation of downstream signaling pathways that regulate cell proliferation, survival, differentiation, and migration.
Signal transduction and variation: EGFR signaling proceeds through homo- or heterodimerization with other ERBB family members
Clinical significance: EGFR alterations are common in several cancers. Activating mutations in non-small cell lung cancer
Diagnostics and research: EGFR status is assessed by immunohistochemistry, fluorescence in situ hybridization, and sequencing. Beyond