ECMafbraak
ECMafbraak is a term used to describe the breakdown or degradation of extracellular matrix (ECM). The extracellular matrix is a complex network of proteins and other molecules that provides structural support to cells and tissues in multicellular organisms. It plays crucial roles in cell adhesion, migration, proliferation, and differentiation.
The breakdown of ECM can occur through various mechanisms, including enzymatic degradation by matrix metalloproteinases (MMPs)
In diseases such as cancer, ECMafbraak is essential for tumor growth, invasion, and metastasis. Cancer cells
Conversely, impaired ECMafbraak can also be problematic. For example, the accumulation of excessive or altered ECM