EAD2A0

EAD2A0 is a protein-coding gene identified in the Homo sapiens genome during large-scale sequencing projects in the early 21st century. The gene is located on chromosome 12 at locus 12q14.2 and spans approximately 1.8 kilobases of genomic DNA. The resulting mRNA transcript is 1,352 nucleotides in length and encodes a protein of 225 amino acids, predicted to have a molecular weight of roughly 24 kDa. Bioinformatic analysis predicts that the encoded protein contains a single transmembrane domain and a short cytoplasmic tail, suggesting a role as a membrane-associated signaling molecule.

Expression profiling indicates that EAD2A0 is ubiquitously expressed at low levels in most adult tissues, with higher transcripts detected in the placenta, fetal liver, and in certain leukemic cell lines. Functional studies in vitro have shown that knockdown of EAD2A0 using siRNA increases susceptibility to apoptosis in response to UV irradiation, hinting at a protective cellular role. No pathogenic variants have yet been conclusively linked to human disease, although a few rare nonsynonymous single-nucleotide polymorphisms have been catalogued in gnomAD without strong evidence of clinical significance.

The protein interacts weakly with ERBB2 and PI3K regulatory subunits in yeast two-hybrid assays, suggesting possible involvement in growth-factor mediated signaling pathways. Further research is required to determine its precise biochemical activity, subcellular localization, and potential as a therapeutic target in malignancies where its expression is upregulated.