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Doppelstrang

Doppelstrang is a term used in biology to refer to a molecule composed of two nucleic acid strands that are complementary and held together by base pairing. The most familiar example is double-stranded DNA, but double-stranded RNA also exists in some viruses and cellular processes. In a typical double-stranded molecule, the two polynucleotide chains run antiparallel, one from the 5' end to the 3' end and the other in the opposite direction. The sugar-phosphate backbones are on the outside, while the bases pair inside: adenine with thymine (or uracil in RNA) and guanine with cytosine. This arrangement forms a double helix in many conditions, most commonly the right-handed B-form in DNA, with major and minor grooves that proteins recognize for regulation and replication. The term "double strand" can also describe alternative DNA forms, such as Z-DNA, which adopts a left-handed helix under certain conditions, and double-stranded RNA, which generally adopts an A-form geometry.

Biologically, the double-stranded arrangement is crucial for storing genetic information and for faithful replication. During cell

division,
the
strands
unwind
and
serve
as
templates
for
copying
the
sequence
in
a
semi-conservative
manner,
aided
by
helicases
and
polymerases.
Post-transcriptionally,
single-stranded
regions
are
required
for
transcription,
repair,
and
recombination.
Double-stranded
molecules
also
participate
in
gene
silencing
and
defense
mechanisms,
notably
in
the
case
of
dsRNA
in
RNA
interference.