Dobesilate

Dobesilate, also known as calcium dobesilate, is a medication primarily used to treat conditions related to venous and lymphatic insufficiency. It is a vasoprotective agent, meaning it helps to protect and strengthen blood vessels. Dobesilate works by increasing the tone of the venous walls, reducing the permeability of capillaries, and improving lymphatic drainage. This action helps to alleviate symptoms such as swelling, pain, and heaviness in the legs, often associated with chronic venous disease, varicose veins, and hemorrhoids.

The mechanism of action of dobesilate is thought to involve its effects on the microcirculation. It is believed to inhibit the release of certain inflammatory mediators and enzymes that can damage blood vessel walls. Additionally, it may have antioxidant properties. Dobesilate is typically administered orally. It is generally well-tolerated, with gastrointestinal disturbances being the most common side effects. It is not recommended for use in individuals with known hypersensitivity to the drug. Its use during pregnancy and breastfeeding should be carefully considered by a healthcare professional. Dobesilate is available in various countries for the management of venous and lymphatic disorders.