Disulfiderich
Disulfiderich describes molecules that contain a high number of disulfide bonds, covalent linkages formed between cysteine thiol groups. In biochemistry, the term denotes proteins and peptides whose structural integrity and stability derive largely from these disulfide connections.
Disulfide-rich proteins are common in oxidizing environments, notably secreted or extracellular compartments. They include defensins, some
Chemistry and structure: Disulfide bonds are formed by oxidation of two cysteine residues to cystine. They
Biological significance and measurement: The disulfide content contributes to folding efficiency and stability, especially for secreted
Examples and applications: Insulin contains multiple disulfide bonds; defensins and conotoxins are classic disulfide-rich peptides. Disulfiderich