Diploidisena

Diploidisena is a hypothetical enzyme proposed in theoretical models to regulate diploidy in eukaryotes that experience ploidy variation. The name combines elements related to diploidy and enzymes, reflecting its suggested role in maintaining a stable diploid state.

In these models, Diploidisena is posited to participate in the maintenance of diploidy by coordinating DNA replication licensing, sister chromatid cohesion, and chromosome segregation during cell division. It is hypothesized to function as a regulator that senses the cellular ploidy state and adjusts replication timing or the activity of cohesion factors to prevent endoreduplication or loss of chromosome copies.

Status and evidence: there is no experimental confirmation of Diploidisena as a distinct biochemical entity. The concept arises from theoretical simulations and comparative genomics that explore how cells might stabilize diploidy under fluctuating ploidy conditions. While related protein families involved in replication licensing and chromosome cohesion exist in many organisms, Diploidisena as an isolated enzyme has not been isolated or characterized in laboratory studies.

Organismal relevance: the idea of Diploidisena contributes to discussions of genome stability and evolutionary transitions between ploidy levels. If real, its discovery could inform approaches to improve the stability of polyploid crops or enhance understanding of how certain protists maintain diploidy amid genome doubling or reduction.

See also: ploidy, polyploidy, meiosis, genome stability, chromosome cohesion, replication licensing.