Digoksiini
Digoksiini, or digoxin in English, is a cardiac glycoside used in the treatment of certain heart conditions.
Mechanism of action and effects
Digoksiini inhibits the Na+/K+-ATPase pump in cardiac myocytes, increasing intracellular sodium and reducing the extrusion of
Digoksiini is used to improve symptoms and exercise tolerance in chronic heart failure with reduced ejection
Pharmacokinetics and monitoring
The drug can be given orally or intravenously. It has variable bioavailability and a large volume of
Digoxin has a narrow therapeutic window. Toxicity can cause gastrointestinal symptoms, confusion, visual disturbances, and potentially
Digoksiini/digoxin remains a classic therapy with a well-established, though narrow, safety margin, used when indicated and