Devascularised

Devascularised (British English) or devascularized (American English) is an adjective used in medicine and biology to describe tissue, an organ, or a region that has had its blood supply removed or severely reduced. The resulting lack of perfusion leads to ischemia and, if circulation is not restored, potential tissue necrosis.

Causes of devascularisation include traumatic injury that severs or damages blood vessels, thrombosis or embolism that blocks arterial or venous flow, inflammatory processes that compromise perfused tissue, or surgical ligation performed to control bleeding or isolate a segment for treatment. It can be an unintended consequence of disease or surgery, or it can be an intentional aspect of a procedure designed to limit blood loss or the spread of disease.

In clinical practice, devascularised tissue typically shows diminished or absent enhancement on contrast imaging, and may appear pale, mottled, or infarcted. Pathologically, ischemic changes are common. Some tissues may be salvaged with prompt reperfusion, whereas prolonged deprivation of blood supply often results in nonviability.

Devascularisation is distinct from revascularization or neovascularization, which describe restoration or creation of blood supply rather than its loss. The term is used across surgical, radiological, and pathological contexts to denote the absence or severe reduction of vascular perfusion in a region or structure.