Desmosomit

Desmosomites are a type of desmosome, which are cell adhesion structures that connect cells. Specifically, desmosomites are a less common, more generalized term referring to desmosomes found in various tissues and cell types, often in contrast to more specialized forms. Desmosomes are intercellular junctions characterized by a dense plaque on the cytoplasmic side of each cell membrane. Intermediate filaments, such as keratins or desmin, are anchored to these plaques, contributing to the structural integrity and mechanical strength of tissues.

These junctions play a crucial role in maintaining the cohesion of epithelial and cardiac muscle tissues, preventing cells from separating under mechanical stress. The extracellular space between the adhering cell membranes is filled with cadherin molecules, specifically desmogleins and desmocollins, which interact to mediate cell-to-cell adhesion. This complex arrangement allows tissues to withstand significant physical forces.

While the term desmosomite is not as widely used as "desmosome" itself, it serves to encompass the broad range of these important adhesive structures. Dysfunctions in desmosome formation or function are implicated in various diseases, including certain skin disorders and cardiomyopathies, highlighting their essential role in tissue health and stability.