Desglymidodrina

Desglymidodrina is a metabolite of midodrine, a medication used to treat orthostatic hypotension. Orthostatic hypotension is a condition where blood pressure drops significantly upon standing, leading to dizziness or fainting. Midodrine works by constricting blood vessels, which helps to raise blood pressure. Desglymidodrina is formed in the body when midodrine is metabolized. It is considered the active metabolite, meaning it is responsible for the pharmacological effects of midodrine.

The primary action of desglymidodrina is to stimulate alpha-1 adrenergic receptors in the smooth muscles of blood vessels. This stimulation causes vasoconstriction, an increase in peripheral vascular resistance, and consequently, a rise in blood pressure. This effect helps to prevent the excessive drop in blood pressure that occurs when a person with orthostatic hypotension stands up.

Desglymidodrina itself is not administered directly as a medication. It is the breakdown product of midodrine that exerts the therapeutic effect. The concentration of desglymidodrina in the bloodstream increases after oral administration of midodrine. The effects of desglymidodrina are generally considered to be longer-lasting than those of midodrine itself, contributing to midodrine's efficacy in managing orthostatic hypotension. Understanding the role of desglymidodrina is crucial for comprehending the pharmacokinetics and pharmacodynamics of midodrine treatment.