DPDcreatinine
DPDcreatinine is a biomarker used to assess dihydropyrimidine dehydrogenase (DPD) activity by measuring urine-based metabolites normalized to creatinine. The concept centers on the role of DPD as the rate-limiting enzyme in the catabolism of pyrimidines, including uracil and thymine, and its influence on the metabolism of fluoropyrimidine chemotherapy agents such as 5-fluorouracil and capecitabine. Lower DPD activity can lead to higher systemic exposure and a greater risk of severe and sometimes life-threatening toxicity.
Measurement typically involves quantifying pyrimidine metabolites, such as uracil and dihydrouracil, in urine and adjusting the
Interpretation of DPDcreatinine values is nuanced. Abnormally low DPDcreatinine indices may indicate reduced DPD activity and
See also: dihydropyrimidine dehydrogenase, DPYD, fluoropyrimidine toxicity, pharmacogenomics, uracil-to-creatinine ratio.