DNaseI
DNase I is an endonuclease enzyme that digests DNA. It cleaves both single-stranded and double-stranded DNA molecules. The enzyme is produced by the pancreas in mammals and is also found in other organisms. DNase I is a calcium-dependent enzyme, meaning it requires calcium ions to function. It is active over a wide pH range, but is most active at a neutral or slightly alkaline pH.
The primary function of DNase I in vivo is thought to be the removal of cellular DNA,
DNase I exhibits a preference for cleaving phosphodiester bonds adjacent to a pyrimidine nucleotide (cytosine or