DNAjono

DNAjono is a fictional concept used in speculative biology and science fiction to describe a programmable DNA editing framework that integrates sequence-level manipulation with the three-dimensional organization of the genome. In this imagined system, edits are planned based on both nucleotide changes and the spatial proximity of regulatory elements within chromatin, with the aim of modulating gene expression in a targeted and reversible manner.

The term DNAjono emerged in online science fiction and bioethics discussions in the 2010s, though its exact origins are unclear. It is commonly employed in world-building, novels, and game lore to explore advanced genome engineering without prescribing a real-world protocol.

In typical fictional treatments, DNAjono relies on a software-hardware interface—often described as a "jono platform"—that maps "jono-sites" in the genome and uses specialized tools, sometimes called "jono-nucleases," to reposition regulatory loops such as enhancers and silencers. The platform is described as including safeguards, audit trails, and multi-step validation to address safety concerns, though the specifics vary by work.

As a fictional construct, DNAjono serves to probe ethical, biosafety, and societal questions surrounding genome editing, including unintended pleiotropy, access, and governance. In actual biology, current gene-editing technologies such as CRISPR-Cas systems operate at the sequence level with ongoing research into higher-order genome architecture, and there is no real-world technology named DNAjono.