DAspartic

Daspartic, also known as D-aspartic acid (D-AA), is the D-enantiomer of the amino acid aspartic acid. It occurs in trace amounts in animals and microorganisms and is studied for its potential roles as a signaling molecule in the neuroendocrine system. In mammals, D-Asp has been detected in brain and reproductive tissues, including the hypothalamus and testes, where it is thought to participate in hormonal regulation.

Biological role and mechanism: D-Asp is proposed to influence the hypothalamic–pituitary–gonadal axis by promoting the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This can lead to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary, with potential effects on testosterone production in males. It has also been observed in certain species during developmental periods. However, findings across studies are inconsistent, and observed effects vary with species, dose, and duration.

Supplementation and research: D-Aspartic acid is marketed as a dietary supplement intended to boost testosterone and support athletic performance. Short-term, small-scale studies in humans have reported mixed results, with some showing modest testosterone increases and others showing no significant change. The long-term effects and safety profile remain less well established, and research results are not uniform regarding its efficacy.

Safety and regulation: D-Aspartic acid is not approved as a therapeutic drug in many jurisdictions and is sold as a dietary supplement. Potential side effects reported anecdotally include headaches and mood changes, and individuals with hormone-sensitive conditions or those planning pregnancy should exercise caution and consult a healthcare provider before use.