DAGactivated
DAGactivated is a term used in biochemistry and systems biology to describe processes, proteins, or pathways activated by diacylglycerol (DAG), a lipid-derived second messenger. In cellular signaling, DAGactivated commonly refers to proteins with a C1 domain that bind DAG, triggering membrane recruitment and functional activation. The best-known example is the protein kinase C (PKC) family, whose isoforms require DAG for activation alongside calcium, initiating phosphorylation cascades. Other DAG-responsive effectors include RasGRP proteins and Munc13 family members.
Biochemically, DAG is produced when phospholipase C cleaves PIP2 in response to receptor stimulation. DAG remains
In computational modeling, DAGactivated can describe nodes that switch on when local DAG levels rise, allowing