Cytokinetargeted
Cytokinetargeted is a term used in biomedicine to describe strategies that aim to modulate cytokines or their signaling pathways to influence immune responses and disease processes. The approach encompasses a range of modalities designed to reduce or redirect the activity of cytokines such as TNF-α, IL-6, IL-1β, and others, or to block their interactions with receptors. It also includes targeting downstream signaling cascades (for example JAK-STAT or MAPK pathways) that transduce cytokine signals.
Therapies in cytokinetargeted approaches include biologics like monoclonal antibodies and soluble receptor fusion proteins that neutralize
Medical applications encompass autoimmune diseases (such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis), autoinflammatory syndromes,
Advantages of cytokinetargeted strategies include the potential for more precise modulation of disease-driving pathways and, in
History and context reflect the field’s evolution from early anti-cytokine therapies to a broad and ongoing